Who should microdose?
What does it do?
Psychedelic micro-dosing is the practice of using sub-threshold doses (micro-doses) of serotonergic psychedelic drugs in an attempt to improve creativity, boost physical energy level, promote emotional balance, increase performance on problems-solving tasks and to treat anxiety, depression and addiction. The practice of microdosing has become more widespread in the 21st century with more people claiming long-term benefits from the practice.
This is not to be confused with Micro-dosing in medical field that is done with other medications. Microdosing, or micro-dosing, is a technique for studying the behaviour of drugs in humans through the administration of doses so low (“sub-therapeutic”) they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied. This is called a “Phase 0 study” and is usually conducted before clinical Phase I to predict whether a drug is viable for the next phase of testing. Human microdosing aims to reduce the resources spent on non-viable drugs and the amount of testing done on animals.
I only want to point out the significant difference in the aim of each drug as to why a micro-dose would be implemented. Psilocybin has shown to have a number of positive effects on a person’s neurological system as well as those persons over all mood and outlook. The chemical compound in psilocybe mushrooms is now showing to help with PTSD, Depression, cognition, Dementia, Alzheimer’s, tinnitus, and creativity. Clinical Studies were done at UCLA that showed that this drug has rapid and drastic effects in altering the structure of the human brain. In essence, it caused the branches of the neurons in the brain to grow.
This has started to change the way of thinking about what is causing depression. In the past, we had understood this as a chemical imbalance in the brain that hindered our brain to perceive feelings of happiness. The depression diagnosis is now being seen as much more complicated than that and that it stems from a structural change in the key neural circuits that regulate emotion in the brain. One of the main indicators of depression is the atrophy of neurons in the prefrontal cortex. This is where the psychedelics come into play. This substance is showing very promising results in its ability to bring neurogenesis to the one micro-dosing.
Schools that have been approved by the FDA for human clinical studies on psilocybe mushrooms are
* John Hopkins
* MacMaster Uni
* LA Bio-Med
* University of Bristol
* UC San Diego
Essentially anyone can microdose with mushrooms. It is both preventative as well and active in its ability to help with mental health and brain cognition. I know in our time, mushrooms are seen as the hippy, liberal, druggies that will not make much of themselves and nothing could be further than the truth. With its benefits in focus and sharpness of mind, many in the academic world and clinical world are taking advantage of its effects and this very exciting new world.
So how would you go about micro-dosing? So a micro-dose is typically going to be 1/10 of one dose of the given drug. The biggest point is that a microdose should not be felt by the one taking it. The user will have little to no effect on how he or she feels. The idea is to get none of the hallucinogenic side effects while getting all of the metabolic effects on the body. For mushrooms, this is going to be somewhere between .1-.3 grams of psilocybe cubensis and that is the chosen mushroom because it is the most readily available and easiest to cultivate. There is also a regiment that you want to follow so that your body doesn’t build up a tolerance to the psilocybin. Using the Stamets method you would dose 4 days on and three days off. This way your body has time to filter it out of your system and receive the next dose ready and fresh.
To get the maximum benefits from the drug it is recommended to stack this with Lions Mane. Which can be a whole study in and of itself. As well as with Vitamin B3 or Niacin. Both will give and promote what is necessary to have the maximum benefits to the body. The Niacin helps in preventing abuse with its flushing properties as well as causing a very annoying skin itch sensation. It also dilates the blood vessels and excites the nerve endings.
I could go on about the amazing properties of these little fungi but you would be here all week. The facts are in and it is proving to be a very wonderful drug in a very scary world. Though psilocybe cubensis are still seen federally as a schedule 1 drug, much like Marijuana. It is being decriminalized across the nation with big wins coming in CO, and CA where the funds have been simply taken away to prosecute anyone in possession. I personally think one of the biggest obstacles with the medicinal use of psychedelics is going to be the public perception and acceptance of it as a legitimate drug.
I love making my micro-doses in chocolates for many reasons. Chocolate is just amazing (I use pure cacao and honey) but I get to add all the other ingredients that I want, lions mane, Mucuna Bean, Niacin, and MTC oil. If you have any questions please feel free to reach out and I will include the base for my chocolate microdoses immediately following the publishing of this post. Also, any resources that you would like please feel free to reach out and I can provide you with what I have. I will also be sharing in the next post my own experience with micro-dosing and the incredible improvements I have seen over the years from a traumatic brain injury I had when I was 18 and on life support after destroying my frontal cortex. Cheers.
Paul Stamets Microdosing study-Microdosing.me